DETERMINATION OF AMFEPRAMONE HYDROCHLORIDE, FENPROPOREX, AND DIAZEPAM IN SO-CALLED “NATURAL” CAPSULES USED IN THE TREATMENT OF OBESITY
作者:
AdeliaE. Almeida,
MariaL. Ribeiro,
Luciana Polese,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 2000)
卷期:
Volume 23,
issue 7
页码: 1109-1118
ISSN:1082-6076
年代: 2000
DOI:10.1081/JLC-100101512
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A simple and rapid method was developed for the determination of amfepramone hydrochloride, fenprorex, and diazepam in capsules using high performance liquid chromatography (HPLC) with UV detection. This procedure provided conditions for the separation of the active ingredient from the complex matrices of the dosage forms by extraction in methanol. Isocratic reversed phase chromatography was performed using acetonitrile, methanol, and aqueous 0,1% ammonium carbonate (50:10:40) as a mobile phase, LiChrospher 100 RP 18 column (125 × 5 mm id, 5μm), a column temperature of 25 ± 1°C and detection at 230 nm.
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