ALLOREACTIVE T SUPPRESSOR CELLS IN THE RATI. EVIDENCE OF THREE DISTINCT SUBSETS OF SPLENIC SUPPRESSOR T CELLS RESISTANT TO CYCLOSPORINE
作者:
M. Freitas Rodrigues,
I. Hutchinson,
P. Morris,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 47,
issue 5
页码: 847-852
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
In this study we examined the effect of cyclosporine on three distinct subsets of T suppressor (Ts) cells identified in a rat renal allograft model. Ts inducer (Ts1) cells having the CD4 marker are found in the spleens of DA rats undergoing acute rejection of LEW kidneys. Transducer (Ts2) and effector (Ts3) cells both carry the CD8 marker and are found in the spleens of long-term surviving DA rats bearing LEW kidney allografts made tolerant by donor-specific blood transfusions or by cyclosporine (in most cases). These latter cells are distinguished by their susceptibility to cyclophosphamide (CY), Ts2 cells being resistant while Ts3 cells are sensitive to CY. When Ts cells from DA rats undergoing acute graft rejection of LEW kidneys or bearing long-term-surviving LEW kidneys that had been treated with cyclosporine (10mg/kg/day) for 2 or 10 days, respectively, were adoptively transferred into lightly irradiated DA recipients, these cells were still able to specifically induce long-term survival of LEW kidneys.
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