Rates of complications associated with a second trimester genetic amniocentesis were studied in 918 patients, and complete infant follow-up was obtained. In 903 singleton pregnancies and 15 twin gestations, the procedure was performed under continuous sector scanning guidance through an attached needle guide. Eight fetal deaths in the 903 cases occurred at less than 28 weeks after amniocentesis (0.89%), none within two weeks after the procedure. Only one fluid was visibly blood contaminated. Comparisons are made with other series from the literature.