Direct enantioselective separation of bevantolol by high‐performance liquid chromatography on normal and reverse cellulose chiral stationary phases
作者:
Hassan Y. Aboul‐Enein,
Vince Serignese,
期刊:
Biomedical Chromatography
(WILEY Available online 1994)
卷期:
Volume 8,
issue 1
页码: 22-25
ISSN:0269-3879
年代: 1994
DOI:10.1002/bmc.1130080106
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractA direct, isocratic and simple chromatographic method is described for the enantiomeric separation of bevantolol (BEV) using normal and reverse cellulose tris (3,5‐dimethylphenylcarbamate) chiral stationary phases (CSPs) known as Chiralcel OD and Chiralcel OD‐R, respectively. The effect of various alcohols present in the mobile phase on the separation factor (α) and resolution factor (Rs) has been studied.The method has been used to determine and identify the BEV enantiomers in human urine after oral administration of racemic BEV. The chiral recognition mechanism(s) between the analyte and these chiral stationary phases is prop
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