Effects of Vitamin E on fibroblast fibronectin
作者:
HelsonLawrence,
HelsonChristiane,
期刊:
Nutrition and Cancer
(Taylor Available online 1985)
卷期:
Volume 7,
issue 4
页码: 221-227
ISSN:0163-5581
年代: 1985
DOI:10.1080/01635588509513858
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractFibronectin is a glycoprotein found mainly on fibroblast cell surfaces. Cultured human skin fibroblasts grow as monolayers in regular linear and whorl‐shaped patterns. Exposure to a certain vitamin E analogue, D‐α‐tocopheryl‐polyethylene‐glycol‐1000‐succinate, induces concentration‐dependent morphological and pattern changes. Using indirect immuno‐fluorescence techniques, fibronectin, a cell protein associated with cell structure and intercellular patterns, was identified within the cells and the intercellular spaces. At a low concentration, the vitamin E analogue caused inhibition of the intercellular distribution of fibronectin without changes in intracellular fibronectin or significant disruption of the morphological patterns. At higher concentrations morphological changes ensued. These data suggest that the mechanism of vitamin E‐induced morphological and intercellular pattern changes may not be manifested through inhibition of fibronectin deposition or secretion.
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