Lack of a modifying effect by the diuretic drug furosemide on the development of neoplastic lesions in rat two‐stage urinary bladder carcinogenesis
作者:
Masa‐Aki Shibata,
Akihiro Hagiwara,
Seiko Tamano,
Satoko Ono,
Shoji Fukushima,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 26,
issue 3
页码: 255-265
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531252
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The effect of the diuretic drug furosemide on two‐stage urinary bladder carcinogene‐sis in F344 rats initiated byN‐butyl‐N‐(4‐hydroxybutyl)nitrosamine (BBN) was investigated with regard to possible promoting activity. BBN was administered at 2 doses, 0.01 or 0.05%, in drinking water for 4 wk, and thereafter furosemide was given by gavage 3 times weekly for 32 wk, 250 mg/kg body weight. Furosemide ingestion induced diuresis with an alkaline, hypotonic urine. No significant difference with regard to incidences of bladder lesions were apparent between furosemide and control groups. The present investigation indicated that neither furosemide nor its related polyuria acted as a promoter in two‐stage urinary bladder carcinogenesis.
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