Intracellular Ca2+-Mg2+Interactions
作者:
Theodor Günther,
Jürgen Vormann,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1994)
卷期:
Volume 17,
issue 6
页码: 279-286
ISSN:1420-4096
年代: 1994
DOI:10.1159/000173842
出版商: S. Karger AG
关键词: Intracellular free magnesium;Intracellular free calcium;Thapsigargin;Thymocytes rat
数据来源: Karger
摘要:
To ascertain possible interactions of intracellular Mg2+ and Ca2+, the concentration of intracellular free Ca2+ ([Ca2+]i) and intracellular free Mg2+ ([Mg2+]i) were experimentally increased within physiological ranges and it was measured by means of fura-2 and mag-fura-2 whether the increased concentration of one divalent cation affected the concentration of the other. A four-fold increase of [Ca2+]i in rat thymocytes by concanavalin A or thapsigargin had no significant effect on [Mg2+]i. Incubation of rat thymocytes in Na+-free medium increased [Mg2+]i from 0.35 to 0.7 mM. This increase in [Mg2+]i did not affect [Ca2+]i or the action of thapsigargin on [Ca2+]i.
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