Atrial natriuretic factor increases in response to an acute glucose load
作者:
Lorenz Böhlen,
Paolo Ferrari,
Michaela Papiri,
Yves Allemann,
Sidney Shaw,
Peter Weidmann,
期刊:
Journal of Hypertension
(OVID Available online 1994)
卷期:
Volume 12,
issue 7
页码: 803-808
ISSN:0263-6352
年代: 1994
出版商: OVID
关键词: Atrial natriuretic factor;acute hyperglycaemia;acute hyperinsulinaemia;plasma osmolality.
数据来源: OVID
摘要:
ObjectiveTo evaluate the effects of an acute glucose load on circulating atrial natriuretic factor (ANF) levels.MethodsWe investigated plasma ANF, glucose and insulin levels before and after intravenous administration of 50% D-glucose (300 mg/kg body weight) in healthy, normal volunteers.ResultsIn study group A (n = 30) plasma ANF was found to be increased significantly 30min after the glucose load. In study group B (n = 55) the response of plasma ANF over time was assessed. A peak plasma ANF response was observed 10min after intravenous glucose loading; thereafter, plasma ANF levels returned gradually to basal levels at 50min after glucose injection. The latter produced in both study groups a similar acute hyperglycaemia, and in group B the expected concomitant hyperinsulinaemia.ConclusionThese observations demonstrate that, in normal humans, acute marked hyperglycaemia is accompanied by a rapid increase in circulating ANF levels. In this metabolic interaction, ANF might counteract the renal sodium-retaining effect of acute hyperglycaemia and hyperinsulinaemia.
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