首页   按字顺浏览 期刊浏览 卷期浏览 Fibrinolysis Inhibition in Human Burn Blister Fluid
Fibrinolysis Inhibition in Human Burn Blister Fluid

 

作者: W B Rockwell,   H P Ehrlich,  

 

期刊: Journal of Burn Care & Rehabilitation  (OVID Available online 1990)
卷期: Volume 11, issue 1  

页码: 1-6

 

ISSN:0273-8481

 

年代: 1990

 

出版商: OVID

 

数据来源: OVID

 

摘要:

Fibrin plate assays revealed that human burn blister fluid represses plasmin-induced fibrinolysis. While this repression is significant, it is not as potent as that of human serum. Ibuprofen, a nonsteroidal anti-inflammatory drug, antagonizes blister fluid inhibition of fibrinolysis. The activity of ibuprofen appears to be unrelated to the synthesis of prostaglandins because other nonsteroidal drugs that were tested, such as indomethacin, imidazole, and tolmetin had significantly less antagonistic activity. This plasmin inhibition, which is contained in burn blister fluid, may contribute to vascular occlusion after burn injury, which leads to secondary dermal ischemia and necrosis in patients traumatized by burns.

 

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