Tyrosine Hydroxylase mRNA Is Increased by Hyperosmotic Stimuli in the Paraventricular and Supraoptic Nuclei
作者:
Scott Young, III,
Marjorie Warden,
Éva Mezey,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 46,
issue 5
页码: 439-444
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124858
出版商: S. Karger AG
关键词: In situ hybridization;Brattleboro rat;Salt-loading;Hypothalamus;Hybridization
数据来源: Karger
摘要:
In situ hybridization histochemistry was used to locate cells containing tyrosine hydroxylase (TH) mRNA in the hypothalami of salt-loaded and Brattleboro rats. The hyperosmotic plasma conditions found in these animals, as compared to control animals, was associated with an increase in detectable TH mRNA-producing cells in the paraventricular and supraoptic nuclei. These results suggest that dopamine synthesized by neurons of those nuclei may participate in the regulation of neuropeptide synthesis and release within the nuclei and the posterior pituitary.
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