Atherosclerosis in Rats Induced by Repeated Breedings, ACTH and Unilateral NephrectomyAcid Mucopolysaccharides, Fibroplasia, Elastosis and Other Changes in Early Lesions
作者:
Bernard Wexler,
Thomas Brown,
Benjamin Miller,
期刊:
Circulation Research
(OVID Available online 1960)
卷期:
Volume 8,
issue 1
页码: 278-286
ISSN:0009-7330
年代: 1960
出版商: OVID
数据来源: OVID
摘要:
Repeatedly-bred rats of both sexes develop subintimal accumulations of acid mucopolysaccharides and fibroblastic proliferation followed by distortion and destruction of elastic lamellae. Fibrosis, endothelial hyperplasia, lipid deposition, calcification and atheromata are also observed. Changes in the elastic tissue occur independently, and later than the alterations of the ground substance and the fibroblasts. Calcification is found in more advanced lesions, showing an affinity for areas rich in mucopolysaccharides. Exogenous ACTH and unilateral nephrectomy augment early atherosclerotic changes associated with multiple breedings.
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