Effect of Aminophylline on Diaphragmatic Contractility in the Piglet
作者:
DENNIS,
MAYOCK THOMAS,
STANDAERT JON,
WATCHKO DAVID,
期刊:
Pediatric Research
(OVID Available online 1990)
卷期:
Volume 28,
issue 3
页码: 196-198
ISSN:0031-3998
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
Minute ventilation, arterial blood gases, arterial pH, cardiac output, and transdiaphragmatic force generation, both during spontaneous ventilation and in response to phrenic nerve stimulation during airway occlusion at end expiration, were measured in nine anesthetized, tracheostomized piglets before and 30 min after parenteral infusion of 20 mg/kg aminophylline. Serum theophylline levels averaged 109 ± 21 μmol/L (19.7 ± 3.7 μg/mL) at 30 min postinfusion. No significant changes were noted in pH, blood gases, blood pressure, or ventilatory measures after aminophylline. Aminophylline infusion also had no effect on transdiaphragmatic force generation at any frequency of phrenic nerve stimulation studied. It is concluded that aminophylline has no effect on diaphragmatic contractility in the quietly breathing, nonfatigued piglet.
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