Acquired Factor VIII Inhibitor in a Non-Haemophilic Patient: Successful Treatment with Plasma Exchange Associated with Factor VIII Concentrate and Immunosuppressors
作者:
M.L. Paracchini,
G.M. Rocchini,
P. Renoldi,
G.F. Fiorina,
P. Gosso,
L. Onida,
A. Geniram,
U. Marini,
A. Gibelli,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1984)
卷期:
Volume 14,
issue 3
页码: 249-252
ISSN:1424-8832
年代: 1984
DOI:10.1159/000215065
出版商: S. Karger AG
关键词: Factor VIII inhibitors;Plasma exchange
数据来源: Karger
摘要:
We report the successful treatment of a 5 5-year-old man with an acquired factor VIII inhibitor, the appearance of which followed surgery for a carcinoma of the biliary tract. The patient, who had recurrent life-threatening bleeding episodes, was treated with intensive plasmapheresis, factor VIII concentrates, azathioprine and methylprednisolone. Disappearance of the inhibitor was observed after the second series of plasma exchanges. Controls 2 and 3 months after treatment confirmed the complete absence of the inhibitor and normal levels of factor VIII. The crucial role of plasma exchange is considered and discussed.
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