Is barakol anxiolytic?
作者:
D. Fiorino,
D. Treit,
J. Menard,
L. termer,
A. Phillips,
期刊:
Behavioural Pharmacology
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 375-375
ISSN:0955-8810
年代: 1998
出版商: OVID
关键词: barakol;anxiolytic;elevated plus-maze;shock-probe burying;rat
数据来源: OVID
摘要:
A recent report suggested that barakol, a biologically active extract of the south-east Asian plant, Cassia siamea, has anxiolytic properties. The purpose of the present study was to replicate and extend these findings by examining the dose–response effects of barakol (0–20mg/kg) in two pharmacologically validated tests of rat anxiety: the elevated plus-maze and the shock-probe burying tests. Although the purity of our sample of barakol was confirmed by chemical analysis, we found no evidence of its anxiolytic effects in either the plus-maze or shock-probe burying tests. Behav Pharmacol 1998; 9:375–378© 1998 Lippincott-Raven Publishers.
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