IDN 5390: a new concept in taxane development
作者:
Giulia Taraboletti,
Gianluca Micheletti,
Raffaella Giavazzi,
Antonella Riva,
期刊:
Anti-Cancer Drugs
(OVID Available online 2003)
卷期:
Volume 14,
issue 4
页码: 255-258
ISSN:0959-4973
年代: 2003
出版商: OVID
关键词: angiogenesis inhibitor;cytostatic agent;cell motility;IDN 5390;microtubules;paclitaxel;taxane
数据来源: OVID
摘要:
IDN 5390 is aseco-derivative cytostatic taxane. Originally selected for its ability to affect endothelial cell motility, the anti-angiogenic properties of IDN 5390 have been documented in experimental models,in vivoandin vitro. Preclinical studies indicate that,in vivo, oral IDN 5390 has a favorable bioavailability, is well tolerated and shows a significant anti-neoplastic activity on a panel of different tumor models, including paclitaxel-resistant tumors. According to its cytostatic rather than cytotoxic nature, frequent administrations of non-toxic doses have proven to be the optimal schedule for IDN 5390 treatment. Preliminary findings suggest the use of this compound in combination with conventional anti-neoplastic therapy. IDN 5390 can be considered the prototype of a new class of well-tolerated, orally available anti-angiogenic taxane derivatives with cytostatic properties.
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