Chronotherapy of Trichlormethiazide in Hypertensive Patients
作者:
Akio Fujimura,
Kyo‐ichi Ohashi,
Akio Ebihara,
期刊:
The Journal of Clinical Pharmacology
(WILEY Available online 1991)
卷期:
Volume 31,
issue 1
页码: 54-57
ISSN:0091-2700
年代: 1991
DOI:10.1002/j.1552-4604.1991.tb01886.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Circadian influence of trichlormethiazide on serum electrolyte levels, lipid levels, and glucose levels were evaluated in 12 hypertensive patients. One tablet of trichlormethiazide (2 mg) was given once a day at 7:00amor 7:00pmfor 8 weeks. The study was done by a crossover design. Twenty—four‐hour urine was collected, and fasting blood samples were obtained during the control period and at the end of each treatment period. The 24‐hour urine level increased slightly after treatment with trichlormethiazide in the morning and evening trials. Urinary excretion of sodium also increased slightly in the morning trial and increased significantly in the evening trial. Serum concentrations of potassium and chloride decreased, and serum uric acid level increased after trichlormethiazide treatment. No significant difference was observed in these parameters between morning and evening trials. Fasting blood glucose levels increased after trichlormethiazide treatment. The increment in blood glucose levels was greater in the evening trial than in the morning trial. These data indicate that the influence of trichlormethiazide on glucose tolerance might vary with its administration
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