Effect of Substance P and Sar9Met(O2)11-Substance P on Cutaneous Capillary Permeability in Guinea Pig Skin
作者:
J.D. Doutremepuich,
A. Barbier,
P. Vilain,
F. Lacheretz,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1992)
卷期:
Volume 5,
issue 3
页码: 171-176
ISSN:1660-5527
年代: 1992
DOI:10.1159/000211034
出版商: S. Karger AG
关键词: Substance P;NK1receptor agonist;Cutaneous capillary permeability;Guinea pig skin;Intradermal injection;Angiotensin converting enzyme inhibitor;Atropine;Norepinephrine;Promethazine;Spantide
数据来源: Karger
摘要:
The purpose of this study was to assess the effect of several drugs on the increase in cutaneous capillary permeability induced by intradermal injection of substance P (SP) and Sar9Met(O2)11-SP in guinea pig skin. On the one hand, the increase in cutaneous capillary permeability was partly reduced by spantide, promethazine, atropine or SR 40037, an inhibitor of the angiotensin-converting enzyme. On the other hand, norepinephrine and B3824, a B2-antagonist of bradykinin, showed an enhancing effect. Our results suggest that the effect of SP and Sar9Met(O2)11-SP in guinea pigs is partly mediated by histamine and acetylcholine, and that there is a relationship between tachykinins and bradykinin.
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