Serum and Cerebrospinal Fluid Vitamin B12 Levels in Demented Patients with CH3—B12 Treatment—Preliminary Study—
作者:
Yoshio Mitsuyama,
Hiroshi Kogoh,
期刊:
Psychiatry and Clinical Neurosciences
(WILEY Available online 1988)
卷期:
Volume 42,
issue 1
页码: 65-71
ISSN:1323-1316
年代: 1988
DOI:10.1111/j.1440-1819.1988.tb01957.x
出版商: Blackwell Publishing Ltd
关键词: vitamin B12;cerebrospinal fluid;dementia
数据来源: WILEY
摘要:
Abstract:The vitamin B12 (VB12) parameter was studied in the serum and cerebrospinal fluid (CSF) of 14 demented patients. Eleven of these patients were in a state of dementia of the degenerative type such as Alzheimer's disease, senile dementia and Pick's disease. The serum VB12 concentration in all the patients was within normal limits, I.e. 500–1,300 pg/ml. There was no significant difference between the CSF‐VBl2 levels and the severity of dementia. The serum and CSF‐VB12 levels of the demented patients did not show any significant elevation after the oral administration of CH3–Bl2, 2 mg per day. On the other hand, there was a marked elevation of both the serum and CSF‐VB12 after an oral medication (2 mg per day) plus intramuscular administrations (500 μg per day). These results confirm that the intramuscular administration of CH3–B12 is an effective way to get a higher value of the serum and CSF
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