On the biological origin of anti‐double‐stranded (ds)DNA antibodies: systemic lupus erythematosus‐related anti‐dsDNA antibodies are induced by polyomavirus BK in lupus‐prone (NZBxNZW) F1hybrids, but not in normal mice
作者:
Knut Fredriksen,
Awuku Osei,
Arnfinn Sundsfjord,
Terje Traavik,
Ole Petter Rekvig,
期刊:
European Journal of Immunology
(WILEY Available online 1994)
卷期:
Volume 24,
issue 1
页码: 66-70
ISSN:0014-2980
年代: 1994
DOI:10.1002/eji.1830240111
出版商: WILEY‐VCH Verlag GmbH
关键词: Autoimmunity;Anti‐DNA;Systemic lupus erythematosus;(NZBxNZW)F1mice;BK virus
数据来源: WILEY
摘要:
AbstractWe have recently demonstrated that polyomavirus BK and isolated BK double‐stranded (ds)DNA have a strong potential for induction of anti‐dsDNA antibodies. Here, data are presented that demonstrate that normal mice (a term used in this report for mice not predisposed to a lupus‐like syndrome) of four different strains responded to both BK virus and BK dsDNA by producing transient antibodies binding preferentially to the viral dsDNA itself. These antibodies did not bind in theCrithidia luciliaeassay, and did not seem to be of pathogenic significance, as neither signs of proteinuria nor immunochemical signs of glomerulonephritis developed in these mice. In contrast, 5‐week‐old (NZBxNZW)F1mice developed strong and persistent anti‐dsDNA antibodies in response to BK virus and BK dsDNA, with similar features to those of anti‐dsDNA antibodies from individuals with systemic lupus erythematosus: they reacted strongly in theCrithidia luciliaeassay and cross‐reacted with viral as well as with mammalian dsDNA. Furthermore, persistent proteinuria and glomerulonephritis, with demonstrable heavy mesangial deposits of immune complexes containing IgG anti‐dsDNA antibodies, developed 2‐‐3 months earlier than in spontaneously autoimmune control mice. The relevance of these observations to a viral origin of anti‐dsDNA antibodie
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