The article describes data collected using Pollock's Health-Related Hardiness Scale (HRHS) in two cultural groups of nurses. The purposes of the study were to verify the workability of the HRHS cross-culturally and to compare the effects of health hardiness in nurses in the United States and Taiwan. A total of 163 American and 615 Taiwanese nurses participated and answered a self-administered questionnaire by using Pollock's 34-item HRHS. Psychometric analyses identified two factors of hardiness that are different from Pollock's factors. Pollock's findings were verified, and the HRHS is valid for measuring hardiness constructs as exemplified by the strong factor loading obtained from this study, which ranged from 0.43 to 0.68 for American nurses and 0.47 to 0.68 for Taiwanese nurses