Analysis of Total Platinum Derived from Cisplatin in Tissue
作者:
MichaelL. Denniston,
LarryA. Sternson,
A.J. Repta,
期刊:
Analytical Letters
(Taylor Available online 1981)
卷期:
Volume 14,
issue 6
页码: 451-462
ISSN:0003-2719
年代: 1981
DOI:10.1080/00032718108081419
出版商: Taylor & Francis Group
关键词: Cisplatin;tissue;atomic absorption;total platinum
数据来源: Taylor
摘要:
A method is described for determining total platinum in tissues of animals receiving cisplatin. The method is based on total combustion of the tissue, leaving a platinum residue devoid of organic material that can be dissolved inaqua regiaand analyzed by carbon-rod furnace atomic absorption spectrophotometry. Combustion eliminates matrix effects in final read-out, providing a means for precisely and reproducibly analyzing a variety of tissues. Platinum levels of 200 ng/0.5 g of sample can readily be analyzed with recoveries from all tissues approaching 100%. The validity of the method is demonstrated by giving rats intravenous doses of cisplatin and subsequently measuring tissue levels of platinum.
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