Hemostatic and healing studies of sodium amylose succinate (IP760)
作者:
Diane L. Jeffery,
Donald P. Dressler,
James M. Anderson,
Michael J. Gallagher,
期刊:
Journal of Biomedical Materials Research
(WILEY Available online 1982)
卷期:
Volume 16,
issue 1
页码: 51-61
ISSN:0021-9304
年代: 1982
DOI:10.1002/jbm.820160108
出版商: John Wiley&Sons
数据来源: WILEY
摘要:
AbstractAcute and chronic studies were performed in the canine model to evaluate a new topical hemostatic agent in terms of initial hemostatic capability and tissue/material interaction during the healing process. IP760, a porous amylose succinate material, was applied to large spenic surface wounds in six acute and twelve chronic animals. Microfibrillar collagen (Avitene) was used in twelve chronic animals for comparison. While the hemostatic capabilities of the two agents were comparable, marked differences were noted in the healing response. In the IP760‐treated wound sites the acute inflammatory response, granulation tissue infiltration with fibrosis and healing occurred earlier and in a more homogeneous manner than in the Avitene‐treated wound sites. Healing of the IP760‐treated wounds occurred concomitantly with the development of granulation tissue and fibrosis and the rapid resorption of the
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