Colocalization of the rat homolog of the von Hippel Lindau (Vhl) gene and the plasma membrane Ca++transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3→42.1
作者:
C.M. Aldaz,
R.S. Yeung,
F. Latif,
M.I. Lerman,
G. Xiao,
D. Trono,
C.L. Walker,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1995)
卷期:
Volume 71,
issue 3
页码: 253-256
ISSN:1424-8581
年代: 1995
DOI:10.1159/000134121
出版商: S. Karger AG
数据来源: Karger
摘要:
Using fluorescence in situ hybridization, we localized the rat homolog of the von Hippel-Lindau gene (Vhl) to rat chromosome band 4q41.3→q42.1. We also mapped the gene encoding the plasma membrane Ca++-transporting ATPase iso-form 2 (Atp2b2) to the same chromosome subregion. These two genes together with Raf1 appear to be members of a large syntenic gene cluster that maps to human chromosome bands 3p25→p26, mouse chromosome bands 6 C3→E, and rat chromosome bands 4q41→q42. Cytogenetic analysis of NRK 52E cells derived from immortalized normal rat kidney epithelial cells revealed an inverted duplication of the region containing this gene
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