Neuromelanin, Neuroleptics and Schizophrenia
作者:
Hisanobu Kaiya,
期刊:
Neuropsychobiology
(Karger Available online 1980)
卷期:
Volume 6,
issue 5
页码: 241-248
ISSN:0302-282X
年代: 1980
DOI:10.1159/000117766
出版商: S. Karger AG
关键词: NA-DA interaction;Neuromelanin;Schizophrenia;Neuroleptic
数据来源: Karger
摘要:
On the assumption that neuromelanin content might be a parameter indicating neuronal activity in the catecholaminergic system, neuromelanin was measured microspectro-photometrically in the substantia nigra and the locus ceruleus of 12 brains of patients who had undergone neuroleptic therapy. Neuromelanin increased with age in both regions of 40 control brains. Although no signifícant difference in melanin content between medicated and control brains was seen, a high negative correlation (r = –0.79) was noted in melanin content between the substantia nigra and the locus ceruleus only in each medicated brain, especially in cases of schizophrenia. The possibility of noradrenergic and dopaminergic interaction is discuss
点击下载:
PDF
(975KB)
返 回