Relationship between Flow Cytometric Parameters, Steroid Receptors, and Menopausal Status in Breast Cancers
作者:
Henry M. Abandowitz,
Kim T. Ow,
Debra Hardy,
David D. Keightley,
Gordon A. Sarfaty,
Allan R. Nash,
期刊:
Oncology
(Karger Available online 1987)
卷期:
Volume 44,
issue 1
页码: 24-29
ISSN:0030-2414
年代: 1987
DOI:10.1159/000226437
出版商: S. Karger AG
关键词: Flow cytometry;Nuclear DNA;Steroid receptors;Menopausal status;Breast cancer
数据来源: Karger
摘要:
Of 163 human breast cancers examined, 68% contained detectable aneuploid populations, whilst 32% had apparently normal DNA distributions. A slightly higher incidence of aneuploidy was observed in pre-menopausal patients (83%) than in post-menopausal patients (66%). Also, pre-menopausal patients had slightly higher proportions of S-phase or cycling (S + G2 + M) cells. Estradiol receptor negative (ER –) tumours from post-menopausal patients were found to have the lowest incidence of aneuploidy (59%) and ER– tumours from pre-menopausal patients the highest (91%). There were no significant differences in the proportions of cycling nuclei when receptor status and menopausal status were considered. A weak relationship is shown to exist between flow cytometric data and two common prognostic indicators of breast cancer, namely receptor status and menopausal sta
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