Clinical Pharmacokinetics of&agr;1-Antitrypsin in Homozygous PiZ Deficient Patients
作者:
Jacques Constans,
Pierre Carles,
Andrèe Boneu,
Jacques Arnaud,
Ala Eldin Tufenkji,
Marie-Christine Pujazon,
Catherine Tavera,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1992)
卷期:
Volume 23,
issue 2
页码: 161-168
ISSN:0312-5963
年代: 1992
出版商: ADIS
数据来源: ADIS
摘要:
A pharmacokinetic study of&agr;1-antitrypsin (ATT) was performed in 2 groups of homozygous PiZ-deficient patients (treated and untreated) and 1 group of healthy volunteers. The distribution of the131I-labelled protein corresponds to a 3-compartment model. The intravenously administered protein diffused quickly to the extravascular compartment where some retention occurred. No significant difference in AAT metabolism was observed between the 3 groups.The half-life of the injected protein is slightly longer than 2.5 days. The AAT protein was not stored. These results confirm the observations collected during the clinical trials. That is, a weekly infusion is necessary to obtain stable serum AAT concentrations. Monthly infusions are unable to maintain a ‘plateau’ phase. The periodicity may be limited to every 2 weeks.
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