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No evidence for an inhibitory effect ofβ‐carotene or of canthaxanthin on the initiation of liver preneoplastic foci by diethylnitrosamine in the rat

 

作者: AstorgPierre,   GradeletSandra,   BergèsRaymond,   SuschetetMarc,  

 

期刊: Nutrition and Cancer  (Taylor Available online 1996)
卷期: Volume 25, issue 1  

页码: 27-34

 

ISSN:0163-5581

 

年代: 1996

 

DOI:10.1080/01635589609514425

 

出版商: Taylor&Francis Group

 

数据来源: Taylor

 

摘要:

AbstractTo test whetherβ‐carotene or canthaxanthin can modulate the initiation of liver preneoplasia by diethylnitrosamine (DEN) in a sequential protocol of hepatocarcinogenesis, for three weeks male weanling rats were fed diets containingβ‐carotene or canthaxanthin (300 mg/kg diet) or excess vitamin A (70,000 IU/kg diet) or were givenβ‐carotene by injection (9 injections at 10 mg/kg body wt ip). On Day 15, all rats were injected with 200 mg DEN/kg body wt ip; later they were submitted to 2‐acetylaminofluorene treatment and to two‐thirds hepatectomy, then to phenobarbital treatment, after whichγ‐glutamyltranspeptidase‐and placental glutathione‐S‐transferase‐positive liver foci were histologically detected. Neitherβ‐carotene (fed or injected), canthaxanthin, nor an excess of dietary vitamin A had an influence on the number and size of preneoplastic liver foci, despite a significant incorporation and persistence in liver of both carotenoids, especially canthaxanthin, and of supplemental vitamin A. These results are in conflict with another report in whichβ‐carotene, given to rats during the initiation phase, was found to strongly inhibit DEN‐induced hepatocarcinogenesis.

 

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