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CD4‐Modified Synthetic Peptides Containing Phenylalanine Inhibit HIV‐1 Infection In Vitro

 

作者: Juan Lasarte,   Pablo Sarobe,   José Golvano,   Isidro Prieto,   Maria Civeira,   Arturo Gullón,   Prem Sarin,   Jesús Prieto,   Francisco Borrás-Cuesta,  

 

期刊: Journal of Acquired Immune Deficiency Syndromes  （OVID Available online 1994）
卷期: Volume 7, issue 2  

页码: 129-134

 

ISSN:0894-9255

 

年代: 1994

 

出版商: OVID

 

关键词: Human immunodeficiency virus type 1;CD4-derived peptides;gp 120;Inhibition of human immunodeficiency virus type 1.

 

数据来源: OVID

 

摘要:

Phenylalanine-containing peptides from CD4 were synthesized based on chemical similarity with active CD4(81–92)-benzylated peptides. The synthetic peptide FYIFFVEDQKEEDD) blocked the binding of gp120 to CD4 and inhibited 50% μ human immunodeficiency virus (HIV)-induced syncytia formation at a concentration (1C50) of 40–50 μM and HIV p17 expression with an 1C50of 67 μM. The peptide is not toxic to cells in vitro. Moreover, acute toxicity studies carried out in Swiss mice showed the peptide to be nontoxic at a dose of 2.000 mg kg. This phenylalanine-substituted CD4 peptide may prove to be useful in the treatment of AIDS.

 

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