Diaphragmatic fatigue produced by constant or modulated electric currents
作者:
Yves Jammes,
Peter Collett,
Patrick Lenoir,
Abdelkalek Lama,
Francis Berthelin,
Charis Roussos,
期刊:
Muscle&Nerve
(WILEY Available online 1991)
卷期:
Volume 14,
issue 1
页码: 27-34
ISSN:0148-639X
年代: 1991
DOI:10.1002/mus.880140106
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: diaphragm;muscle fatigue;nerve stimulation;phrenic nerve;rabbit
数据来源: WILEY
摘要:
AbstractIn anesthetized rabbits the efficiency of phrenic nerve stimulation with trains of electric current was studied either when ventilation was effected entirely by bilateral nerve stimulation (electrophrenic ventilation) or during unilateral nerve stimulation when animals were ventilated with a pump and open chest. Trains of rectangular electric pulses (RPT) with constant amplitude and frequency or sine waves, both the amplitude and frequency of which were modulated and controlled by a computer (MSWT), were used with each animal. MSWT closely reproduced the physiological shape of transdiaphragmatic pressure waves. Diaphragm fatigue, as determined from the decrease in the maximal relaxation rate of twitches, occurred after 20 minutes of bilateral or unilateral nerve stimulation with RPT, but only after 60 min (unilateral stimulation) or 98 min (bilateral stimualtion) with MSWT. These data show the importance of the motor signal pattern in long‐lasting nerve stimulatio
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