ObjectiveTo determine whether there is sufficient evidence of a benefit of hemofiltration or plasma filtration in sepsis.Data SourcesMedline search, search of references in articles found in Medline search, literature known to local experts.Study SelectionTrials and reports where clinical outcome measures were included.Data ExtractionClinically relevant information was presented.Data SynthesisStudies were grouped according to hemofiltration or plasma filtration and within each of these groups into animal or human studies; then they were graded from case report, through case series, nonrandomized trials, and randomized trials.ConclusionThere is a lack of randomized trials. The available studies show an absence of benefit for hemofiltration. Further studies are needed in plasma filtration.