The Effects of a Benzodiazepine Antagonist Ro 15–1788 in the Presence of Stable Concentrations of Midazolam
作者:
Peter Lauven,
Helmut Schwilden,
Horst Stoeckel,
David Greenblatt,
期刊:
Anesthesiology
(OVID Available online 1985)
卷期:
Volume 63,
issue 1
页码: 61-64
ISSN:0003-3022
年代: 1985
出版商: OVID
关键词: Anesthetics, intravenous;midazolam;Antagonists, miscellaneous;benzodize-pines, Ro 15–1788;Hypnotics;benzodiazepines, midazolam
数据来源: OVID
摘要:
The benzodiazepine antagonist Ro 15–1788 was administered in a 10-mg intravenous bolus dose to seven healthy young adult volunteers to evaluate the drug's efficacy and duration of action against midazolam. A steady state serum concentration of midazolam was obtained by an initial fast infusion rate of 6.0 mg/min (duration: 10 min) and a maintenance infusion rate of 0.275 mg/min. After administering the antagonist, all subjects opened their eyes without any command in a median time of 36 s (range: 28–48 s). Their personal, temporal and local orientation was reestablished within 54–120 s (median time: 65 s). The subjects fell deeply asleep, again in a median time of 145 min (range: 115–150 min), which was interpreted as an indication of the returning action of midazolam, which was infused for a total period of 210 min. Ro 15–1788 deserves further study as an antagonist, since it could prove useful in the management of benzodiazepine overdosage and in the reversal of benzodizepine action following surgical anesthesia and in the intensive care.
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