Post-synaptic Alpha-blockade and Brachial Artery Compliance in Essential Hypertension
作者:
Jaime Levenson,
Alain Simon,
Jean Bouthier,
Atanave Benetos,
Michel Safar,
期刊:
Journal of Hypertension
(OVID Available online 1984)
卷期:
Volume 2,
issue 1
页码: 37-41
ISSN:0263-6352
年代: 1984
出版商: OVID
关键词: Essential hypertension;arterial compliance;large arteries;pulsed Doppler;alpha1blockade
数据来源: OVID
摘要:
Central (six patients) and brachial (12 patients) haemodynamics were studied in men with sustained essential hypertension before and after intravenous administration of an alpha post-synaptic adrenergic blocking drug, urapidil. Brachial arterial compliance was evaluated non-invasively from the simultaneous measurement of pulse wave velocity and arterial diameter. In basal conditions, arterial compliance was reduced in hypertensives. Urapidil caused a significant drop in blood pressure, due to a significant decrease in total peripheral resistance with no change in cardiac output and heart rate. Brachial arterial diameter and compliance did not change significantly. The results show that the decreased arterial compliance in hypertensive patients was not due exclusively to the elevation of blood pressure or to a predominant activation of the autonomic nervous system, or both. Such observations suggest that, in men with sustained essential hypertension, the decreased compliance was probably related to structural alterations of large arteries.
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