A Correlation Between Plasma Renin Activity and the Pressor Response to Angiotensin II.
作者:
DeheneffeJ.,
BernardA.,
期刊:
Acta Clinica Belgica
(Taylor Available online 1974)
卷期:
Volume 29,
issue 5
页码: 304-312
ISSN:1784-3286
年代: 1974
DOI:10.1080/17843286.1974.11716948
出版商: Taylor&Francis
数据来源: Taylor
摘要:
SummaryWhen angiotensin II was infused into fifty-one unselected subjects a linear relationship was found between the increment of diastolic blood pressure and the logarithm of the rate of infusion of angiotensin II. The slope of this line was found to be very reproducible on repeated determinations in the same subject.When the correlations between pre-infusion plasma renin activity and various functions derived from dose-response curve were determined, it was observed that :1) the significance of the correlation became progressively stronger when increasing thresholds of the pressor response to angiotensin II were considered ;2) the best correlation was achieved when the slopes of the individual dose-response curves were plotted against the logarithm of corresponding plasma renin activities.These results suggest that the slope of the pressor dose-response curve is the most reliable index of responsiveness to intravenously infused angiotensin II ; and that it may provide a satisfactory guide to the basal plasma renin activity.
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