The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and d -amphetamine and is not self-administered
作者:
P.M. Beardsley,
P. Sokoloff,
R.L. Balster,
J.-c. Schwartz,
期刊:
Behavioural Pharmacology
(OVID Available online 2001)
卷期:
Volume 12,
issue 1
页码: 1-11
ISSN:0955-8810
年代: 2001
出版商: OVID
关键词: BP 897;cocaine;d -amphetamine;self-administration;drug-discrimination;mouse;rhesus monkey
数据来源: OVID
摘要:
Growing attention has been directed towards the potential involvement of the dopamine D3 receptor (D3R) in modulating effects of psychomotor stimulants. BP 897 (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylcarboxamide; aka BP 4.897 and DO897) is amongst the most selective partial agonists for the D3R receptor thus far reported. BP 897 was tested for its ability to support self-administration in rhesus monkeys (0.3–30 μg/kg) and for its ability to produce cocaine- and d -amphetamine-like discriminative stimulus effects in mice (0.01–17 mg/kg i.p.). BP 897 was not self-administered above vehicle and saline levels in any of the four monkeys tested, and produced less than 30% generalization from either the cocaine or d -amphetamine stimulus. When BP 897 was administered before administrations of cocaine or d -amphetamine, percent drug-lever selections were reduced. These results suggest that BP 897 has a profile of activity suitable for consideration as a potential treatment for cocaine dependency disorders.
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