Acute Renal Failure Secondary to Leukocyte-Mediated Acute Glomerular Injury
作者:
JennetteJ. Charles,
FalkRonald J.,
期刊:
Renal Failure
(Taylor Available online 1992)
卷期:
Volume 14,
issue 3
页码: 395-399
ISSN:0886-022X
年代: 1992
DOI:10.3109/08860229209106648
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Acute glomemlonephritis can cause acute renal failure. Activated neutrophils and monocytes are major eflectors of glomerulonephritic renal failure. Adhesion molecules, granule enzymes, reactive oxygen radicals, lipid metabolites, and cytokines of activated neutrophils and monocytes mediate glomerular capillary constriction, occlusion, and destruction. Injurious products and biologically active mediators released by activated leukocytes have profound fictional eflects on mesangial cells and endothelial cells, which in turn participate in the disturbance of glomerularfinc-tion, for example, by altering capillary diameter and surface area. f i e glomerular injlammatory events result in decreased glomerular capillary ultrajiltraton coefl-cient and glomerular jiltration rate, as well as other functional perturbations.
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