Increasing-dose gemcitabine plus low-dose cisplatin in metastatic non-small cell lung cancer
作者:
Angel Artal-Cortés,
Javier Martínez-Trufero,
Ana Herrero,
Teresa Puértolas,
Vicente Alonso,
Mónica Corral,
Concepción Ceballos,
Joan Maurel,
Antonio Antón,
期刊:
Anti-Cancer Drugs
(OVID Available online 2003)
卷期:
Volume 14,
issue 2
页码: 111-118
ISSN:0959-4973
年代: 2003
出版商: OVID
关键词: cisplatin;increasing-dose gemcitabine;metastatic non-small cell lung cancer;phase I trial
数据来源: OVID
摘要:
Gemcitabine, a pyrimidine analog active in non-small cell lung cancer (NSCLC), is widely used with cisplatin. The potential activity of the combination has not been fully assessed: gemcitabine is not used at its maximum tolerated dose (MTD) and cisplatin shows a clearly dose-related toxicity. This trial was designed to assess the MTD and dose-limiting toxicity (DLT) of low-dose cisplatin and increasing gemcitabine dose. Chemotherapy: cisplatin 50 mg/m2on day 1, gemcitabine starting at 1400 mg/m2on days 1 and 8 every 21 days. Subsequent levels were increased by 200 mg/m2. Forty-two patients with metastatic NSCLC were enrolled (37 males; median age 61 years; squamous cell carcinoma 19 patients; performance status 2, in 13 patients; 18 patients had significant weight loss). MTD was found to be 2600 mg/m2because of DLT in three of six patients: two neutropenic fever and one massive bleeding. Overall toxicity was generally mild consisting mainly of neutropenia. Asthenia was the most common non-hematological effect. Overall response rate was 19 out of 41 patients (46.3%) and median survival was 31 weeks. We conclude that the recommended dose for a phase II dose is gemcitabine 2400 mg/m2days 1 and 8 as a 30-min infusion when given with cisplatin 50 mg/m2.
点击下载:
PDF
(110KB)
返 回