ELECTRODIAGNOSTIC CHARACTERISTICS OF WEGENER'S GRANULOMATOSIS-ASSOCIATED PERIPHERAL NEUROPATHY
作者:
Hernan Jimenez-Medina,
Stuart Yablon,
期刊:
American Journal of Physical Medicine and Rehabilitation
(OVID Available online 1992)
卷期:
Volume 71,
issue 1
页码: 6-11
ISSN:0894-9115
年代: 1992
出版商: OVID
关键词: Wegener's Granulomatosis;Vasculitis;Neuropathy;Electrodiagnosis
数据来源: OVID
摘要:
Wegener's granulomatosis is a multisystem disease distinguished by a triad of necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis and systemic, small vessel vasculitis. The latter can cause neurologic manifestations when the vasa nervorum are affected. A 53-yrold male presented with a 3-mo history of chronic nasal congestion, arthralgias, pruritic maculopapular eruption, epistaxis and lower extremity weakness. Subsequent lung and chest wall biopsies confirmed diagnosis of Wegener's granulomatosis. Summary of electrodiagnostic data obtained on initial presentation and comparison with later study indicated a sensorimotor polyneuropathy with widespread axonal involvement noted particularly in the distal lower extremity musculature. Electrodiagnostic documentation of rapid progression proved useful in directing alteration of immunosuppressive therapy, with favorable clinical and functional outcome. We believe this is the second case presented of a patient with documented Wegener's granulomatosis and overt clinical evidence of polyneuropathy in whom both electroneurographic and electromyographic studies are described. Electrodiagnostic results are presented with discussion of pertinent literature.
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