Factor V Leiden is not responsible for stroke in patients with sickling disorders and is uncommon in African Americans with sickle cell disease
作者:
Marc J. Kahn,
Charles Scher,
Marta Rozans,
Robert K. Michaels,
Cindy Leissinger,
John Krause,
期刊:
American Journal of Hematology
(WILEY Available online 1997)
卷期:
Volume 54,
issue 1
页码: 12-15
ISSN:0361-8609
年代: 1997
DOI:10.1002/(SICI)1096-8652(199701)54:1<12::AID-AJH2>3.0.CO;2-7
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: thrombosis;hemoglobinopathy;PCR
数据来源: WILEY
摘要:
AbstractCerebrovascular accidents in patients with sickle cell anemia are among the most devastating complications of the disease. It has recently been demonstrated that some patients have a hypercoagulable state on the basis of the presence of an abnormal factor V molecule, factor V Leiden. We undertook this study to evaluate the presence of factor V Leiden in sickle cell patients with stroke. Eighty‐two patients with either Hgb SS, Hgb SC, or Hgb Sβ+‐thalassemia comprised the study population. Of the 82 patients in the study, 19 of them had a history of stroke. In our study population, none of the stroke patients possessed the factor V Leiden mutation. One of the non‐stroke patients was a heterozygote for the mutation (P= 1.00). The overall frequency of the factor V Leiden allele in our population is 0.6%. The estimated prevalence for this mutation is reportedly between 3 and 7% in Caucasian populations. We conclude that the gene frequency for factor V Leiden is less common in Africa Americans with sickle cell disease. Furthermore, factor V Leiden does not appear to be responsible for the development of stroke in sickle cell patients. Am. J. Hematol. 54:12–15, 1997. © 1997 Wiley
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