Data are presented demonstrating the degree to which the mass range of monopole and quadrupole mass spectrometers may be extended by various techniques and concomittant effects that this mass range extension has on the other operating parameters such as resolving power, sensitivity, and mass discrimination. These data indicate that high sensitivity and unit resolution may be maintained over a mass range of greater than 600 amu in a monopole instrument of modest size. Further extension is also possible if resolution or sensitivity may be sacrificed.