Association of elastin with pseudoexfoliative material: an immunoelectron microscopic study
作者:
YiZong,
StreetenBarbara W.,
WallaceRobert N.,
期刊:
Current Eye Research
(Taylor Available online 1988)
卷期:
Volume 7,
issue 12
页码: 1163-1172
ISSN:0271-3683
年代: 1988
DOI:10.3109/02713688809033220
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Using immunoelectron microscopy, the presence of elastin and tropoelastin was demonstrated in pseudoexfoliative (PSX) material in all its classical sites on the lens capsule, ciliary non-pigment epithelium, iris epithelium and stroma, and conjunctiva. Some variability in binding affinity was seen in different sites, and labelling was more often on the periphery than the center of the PSX fibers. The elastin epitope on PSX material was more sensitive to processing than the remarkably stable epitope on mature elastic fibers. Since neither elastin nor a related component of PSX fibers, elastic microfibrillar protein, is a circulating protein, both are likely to be secreted by local ocular cells. Most of these local cells are not involved in elastogenesis normally, suggesting that an abnormal stimulus or defective regulation of matrix synthesis exists in this disease.
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