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Age-Related Incidence of Reperfusion- and Reoxygenation-induced Ventricular Tachyarrhythmias in the Isolated Rat Heart

 

作者: Marco Pahor,   Marco Di Gennaro,   Alberto Cocchi,   Roberto Bernabei,   Luciana Carosella,   Pierugo Carbonin,  

 

期刊: Gerontology  (Karger Available online 1985)
卷期: Volume 31, issue 1  

页码: 15-26

 

ISSN:0304-324X

 

年代: 1985

 

DOI:10.1159/000212677

 

出版商: S. Karger AG

 

关键词: Rat heart;Ventricular tachyarrhythmias;Myocardial contracture;Cell calcium homeostasis

 

数据来源: Karger

 

摘要:

Reperfusion- and reoxygenation-induced ventricular tachyarrhythmias were studied on 6-month-old (adult) and 24-month-old (senescent) Langendoríf perfused rat hearts. The incidence of arrhythmias was significantly higher in the group of senescent hearts. Furthermore, the reperfusion- and reoxygenation-induced contracture was also more frequent in the group of senescent hearts. The interrelation between contracture and arrhythmias might represent an indirect evidence to suggest that alterations in cell calcium homeostasis have an important role in the origin of both phenomena and, possibly, in their increased incidence in the senescent heart

 

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