Age-Related Incidence of Reperfusion- and Reoxygenation-induced Ventricular Tachyarrhythmias in the Isolated Rat Heart
作者:
Marco Pahor,
Marco Di Gennaro,
Alberto Cocchi,
Roberto Bernabei,
Luciana Carosella,
Pierugo Carbonin,
期刊:
Gerontology
(Karger Available online 1985)
卷期:
Volume 31,
issue 1
页码: 15-26
ISSN:0304-324X
年代: 1985
DOI:10.1159/000212677
出版商: S. Karger AG
关键词: Rat heart;Ventricular tachyarrhythmias;Myocardial contracture;Cell calcium homeostasis
数据来源: Karger
摘要:
Reperfusion- and reoxygenation-induced ventricular tachyarrhythmias were studied on 6-month-old (adult) and 24-month-old (senescent) Langendoríf perfused rat hearts. The incidence of arrhythmias was significantly higher in the group of senescent hearts. Furthermore, the reperfusion- and reoxygenation-induced contracture was also more frequent in the group of senescent hearts. The interrelation between contracture and arrhythmias might represent an indirect evidence to suggest that alterations in cell calcium homeostasis have an important role in the origin of both phenomena and, possibly, in their increased incidence in the senescent heart
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