5‐HT2Areceptor gene promoter polymorphism – 1438G/A and mood disorders
作者:
Koichi Ohara,
Miho Nagai,
Toshio Tsukamoto,
Kunihiko Tani,
Yasuo Suzuki,
Kenshiro Ohara,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 6
页码: 1139-1141
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Anorexia nervosa;Depression;5-HT2Areceptor;Mood disorders;Polymorphism;Promoter;Serotonin
数据来源: OVID
摘要:
A-HT2Areceptor promoter polymorphism, −1438G/A, was reported to be significantly increased in patients with anorexia nervosa when compared with controls. In practice, many patients with anorexia nervosa suffer from mood disorders. Furthermore, 5-HT2Areceptors are thought to play a role in the etiologies of mood disorders. Thus, we studied the polymorphism in 95 Japanese patients with mood disorders and 106 healthy Japanese controls. The allele frequency for the −1438G/A polymorphism did not differ between the patients and controls. In addition, the genotype frequencies did not differ according to the subdiagnosis, age of onset, family history of psychiatric illness or suicide attempts.
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