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Multidrug Resistance Due to P-Glycoprotein

 

作者: BurtRichard K.,   FojoAntonio Tito,   ThorgeirssonSnorri S.,  

 

期刊: Hospital Practice  （Taylor Available online 1990）
卷期: Volume 25, issue 4  

页码: 67-77

 

ISSN:2154-8331

 

年代: 1990

 

DOI:10.1080/21548331.1990.11703935

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

P-glycoprotein is a cell membrane transport protein in various human tissues that acts as an efflux pump, apparently to protect normal cells from environmental toxins. It is also a mechanism used by some cancer cells to resist chemotherapy. The gene responsible for P-glycoprotein is partially defined. Agents that inhibit the protein in tumors may make chemotherapy more effective and less toxic.

 

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