A Quantitative Analysis of Placental Vasculature in the Third-Trimester Fetus With Autosomal Trisomy
作者:
BURTON ROCHELSON,
CYNTHIA KAPLAN,
EDWIN GUZMAN,
MICHAEL ARATO,
KATRINA HANSEN,
CAROLYN TRUNCA,
期刊:
Obstetrics & Gynecology
(OVID Available online 1990)
卷期:
Volume 75,
issue 1
页码: 59-63
ISSN:0029-7844
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
Growth disturbance in the trisomic fetus is believed to be primarily fetal in origin. There has been only sparse description of placental pathology in the third trimester in these fetuses, and therefore the placental role in their growth and development remains unexplored. We performed quantitative morphometric analysis on the placentas of 18 fetuses with trisomy and ten normal control fetuses. Doppler umbilical artery analysis was performed on ten abnormal fetuses and all controls. The placentas of trisomic fetuses exhibited a significant reduction in small muscular artery count and small muscular artery/villus ratio. Abnormal Doppler waveforms correlated closely with reduced small muscular artery counts. Undervascularization and increased vascular resistance of the placenta of trisomic fetuses may contribute to diminished fetal growth. The placenta appears to be another fetal organ whose structure and function are affected adversely by abnormal karyotype.
点击下载:
PDF
(431KB)
返 回