NMR Studies of Saccharide Hydrazones, Thiosemicarbazones and Azines: Model Compounds for Immobilisation Studies
作者:
HelenJ. Tweeddale,
JohnW. Redmond,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1998)
卷期:
Volume 17,
issue 1
页码: 27-38
ISSN:0732-8303
年代: 1998
DOI:10.1080/07328309808005766
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
To evaluate possible chemical strategies for the solid-phase immobilization of sugars, studies on the formation and stability of hydrazones, thiosemicarbazones and azines of D-glucose and 2-acetamido-2-deoxy-D-glucose, and the subsequent release of sugars, were carried out. Hydrazone formation was observed to occur under milder conditions than previously reported, thereby minimising the accompanyingN-deacetylation which occurs withN-acetamido sugars. The cyclic β-pyranosyl structures of the saccharide hydrazones, thiosemicarbazones and azines were the preferred isomers in aqueous solution.
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