Amelioration of Frozen Gait by Tandospirone, a Serotonin 1A Agonist, in a Patient with Pure Akinesia Developing Resistance to L-threo-3,4-dihydroxyphenylserine
作者:
Shinji Miyata,
Takashi Hamamura,
Junji Yoshinaga,
Yasushi Nakamura,
Takaki Imamura,
Akiyoshi Hikiji,
Shigetoshi Kuroda,
期刊:
Clinical Neuropharmacology
(OVID Available online 2001)
卷期:
Volume 24,
issue 4
页码: 232-234
ISSN:0362-5664
年代: 2001
出版商: OVID
关键词: Pure akinesia;Frozen gait;L-threo-DOPS;Tandospirone;Noradrenaline-Serotonin
数据来源: OVID
摘要:
A 71-year-old woman presented with severe akinesia, frozen gait, and compromised postural reflexes, without rigidity, tremor, or vertical gaze disturbance. With a working diagnosis of pure akinesia, we administered amantadine (150 mg/d) and L-threo-3,4-dihydroxyphenylserine (DOPS) (600 mg/d), which alleviated her symptoms. When frozen gait recurred 2 months later, we increased the dose of L-threo-DOPS to 900 mg/d and added levodopa (300 mg/d) combined with carbidopa, but this failed to improve the patient's symptoms. We then combined administration of tandospirone, a serotonin (5-HT) 1A agonist with L-threo-DOPS (600 mg/d), resulting in marked clinical improvement. Tandospirone is reported to activate noradrenergic neurons via the 5-HT 1A receptor, which could account for such striking improvement in a patient previously responsive to the noradrenergic precursor L-threo-DOPS given alone.
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