The Anticytokine Neuropeptide α-Melanocyte-Stimulating Hormone in Synovial Fluid of Patients with Rheumatic Diseases: Comparisons with Other Anticytokine Molecules
作者:
Anna Catania,
Valeria Gerloni,
Samuele Procaccia,
Lorena Airaghi,
Maria G. Manfredi,
Claudia Lomater,
Luca Grossi,
James M. Lipton,
期刊:
Neuroimmunomodulation
(Karger Available online 1994)
卷期:
Volume 1,
issue 5
页码: 321-328
ISSN:1021-7401
年代: 1994
DOI:10.1159/000097183
出版商: S. Karger AG
关键词: α-Melanocyte stimulating hormone;Interleukin-1 receptor antagonist;Tumor necrosis factor receptor;soluble;Rheumatoid arthritis;Arthritis;juvenile chronic
数据来源: Karger
摘要:
The aim of this study was to determine if the anticytokine neuropeptide α-melanocyte-stimulating hormone (α-MSH) occurs, along with interleukin 1 receptor antagonist (IL-1ra) and soluble tumor necrosis factor receptor (sTNFr), in synovial fluid of patients with rheumatoid arthritis (RA), juvenile chronic arthritis (JCA), or osteoarthritis. The data show that α-MSH does occur in the synovial fluid and its concentrations are greater in patients with RA than in those with osteoarthritis. Synovial fluid concentrations of IL-1ra and sTNFr were likewise greater in RA. Further, concentrations of α-MSH, IL-1ra, and sTNFr were greater in patients with polyarticular/systemic-onset JCA than in those with pauciarticular disease, that is in patients with greater joint inflammation. Concentrations of α-MSH were greater in synovial fluid than in plasma in a substantial proportion of patients, suggesting local production of the peptide; this is the first indication that the anticytokine molecule α-MSH is produced within a site of inflammation. Further, it appears that local production of α-MSH is induced particularly in those arthritic joints that have more intense inflammatory reactions. This finding, combined with previous evidence of the marked anti-inflammatory activity of α-MSH, suggests that the peptide acts locally to modulate proinflammatory influences in rheumatic d
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