Influence of Indoles (Melatonin, Serotonin and Tryptophan) on the Porphyrin Metabolism in vitro
作者:
K. Kalka,
C. Fritsch,
K. Bolsen,
B. Verwohlt,
G. Goerz,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1997)
卷期:
Volume 10,
issue 4
页码: 221-224
ISSN:1660-5527
年代: 1997
DOI:10.1159/000211507
出版商: S. Karger AG
关键词: Melatonin;Serotonin;Tryptophan;δ-Aminolevulinic acid;Porphyrin metabolism
数据来源: Karger
摘要:
We examined the influence of melatonin, serotonin and tryptophan on the basal and δ-aminolevulinic acid (ALA)-induced porphyrin content in HaCaT, SKMel-23 and HepG2 cells. ALA-preincubated and ALA-free cells were fed with medium containing 1 mM melatonin, serotonin or tryptophan. After 24 h the porphyrin content in the cells and in the culture medium was measured. In the three cell lines the inbucation with 1 mM HaCaT cells. In HepG2 cells, neither melatonin, serotonin nor tryptophan influenced ALA-induced porphyrin concentrations significantly, but all three indoles depressed the porphyrin levels in SKMel-23 and HaCaT cells. The indoles may decrease the ALA uptake in HaCaT or SKMel-23 cells. Another mechanism could be the inhibition of enzymes converting ALA into porphyrins
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