Captopril Modified Silver Electrode and Its Application to the Electroanalysis of Hemoglobin
作者:
Junjie Zhu,
Yue Gong,
Genxi Li,
Hongyuan Chen,
Dexu Zhu,
期刊:
Analytical Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 6
页码: 1097-1107
ISSN:0003-2719
年代: 1997
DOI:10.1080/00032719708004041
出版商: Taylor & Francis Group
关键词: chemically modified electrode;Bioelectrochemistry;Hemoglobin;Captopril
数据来源: Taylor
摘要:
Captopril, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-Proline, can be deposited onto a silver electrode by a covalent bonding method to give a long-lived and stable chemically modified electrode(CME). Since the CME is prepared with a reaction between captopril and the substrate silver, the CME being prepared by this method is very stable. Furthermore, Hemoglobin(Hb) exhibits excellent voltammetric response at the modified electrode. Differential pulse voltammetric(DPV) measurements of the protein with this CME reveal the existence of a linear relationship between the anodic peak current and the concentration of Hb in the range of 2×10−6∼ 5×10−5mol/L. The detection limit is 8×10−7mol/L and the relative standard deviation of results is 5% for 6 successive determinations at 2×10-5mol/L. The determination of Hb for a real example is carried out.
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