Monolayers as Membrane Models. A Study of Antibiotic Action on Lipids
作者:
A. Hochapfel,
H. Hasmonay,
M. Jaffrain,
P. Peretti,
期刊:
Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals
(Taylor Available online 1992)
卷期:
Volume 215,
issue 1
页码: 221-228
ISSN:1058-725X
年代: 1992
DOI:10.1080/10587259208038528
出版商: Taylor & Francis Group
关键词: monolayer;dipalmitoylphosphatidylcholine;monensin;docosanoic acid;lasalacid;octadecanol
数据来源: Taylor
摘要:
Langmuir films of the lipids dipalmitoylphosphatidylcholine, docosanoic acid and octadecanol, in presence of two antibiotic ionophores, monensin sodium salt and lasalocid sodium salt have been studied. An important area increase as a consequence of antibiotic addition has been observed in the π-A isotherms of the phospholipid. The effect has been considered as a result of ionic cavity formation accompanied by rearrangements in the lipid hydrocarbon chains. A smaller area increase of monolayers from the single chain lipids has been observed only when monensin sodium salt was added. Monolayer studies of monensin sodium salt allowed molecular area estimations of the pure antibiotic in the film.
点击下载:
PDF (358KB)
返 回